L-PGA protects cortical neurons against Glu-induced neurotoxity which may be related to inhibition of NO formation or suppression of the rise in i.Įnzymatic production of α-ketoglutaric acid from l-glutamic acid via l-glutamate oxidase. ![]() L-PGA also attenuated Glu-induced NO release. L-1)-induced neuronal loss in a concentration-dependent manner with IC50 value of (41 +/- 9) mumol. In primary cortical cultures from 16-d-old fetal rat, neuronal viability and contents of nitrite in the bathing medium after transient exposure to sodium glutamate ( Glu) were measured with Fura 2-AM as an intracellular calcium indicator, AR-CM-MIC cation measurement system was used to examine cytosolic free calcium (i). To evaluate the effects of L-pyroglutamic acid ( L-PGA, L-5-oxo-2-pyrrolidinecaroxylic acid) on sodium glutamate-induced neurotoxicity in rat cortical neurons. ![]() ![]() L-pyroglutamic acid protects rat cortical neurons against sodium glutamate-induced injury.
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